Measures of GFR that correlate well with inulin clearance. Isotopic markers 51 chromium ethylene-diamine-tetra-acetic acid ( 51 Cr-EDTA), 99 technetium-labelled diethylene-triamine-pentacetate ( 99 Tc-DTPA) and 125 I-iothalamate,Īs well as non-radioisotopically labelled markers like iohexol, produce Ideal exogenous marker is inulin, and it is the gold standard. Plasma clearance markers may be endogenous or exogenous. Plasma clearance markers for measured GFR (mGFR) Exogenous markers GFR is adjusted to a standard body surface area (BSA) of 1.73 m 2 for adults. GFR varies according to age, gender and body size. Metabolised within the kidney and not reabsorbed from the filtrate. Kidneys, freely filtered by glomeruli, not secreted, synthesised or In order for the clearance of a substance toīe the same as the GFR the clearance marker should be in a stableĬoncentration in the plasma, eliminated from the blood only by the Measurement of the GFR is based on the plasma clearance of a substanceīy glomerular filtration. Glomerular filtration is an essential function of the kidneyĪnd the glomerular filtration rate (GFR) is generally accepted as theīest overall measure of the functioning renal mass in both health and Several laboratories within the Central region of the NHLS.Ĭorrespondence to: Jocelyn Naicker filtration rate Specialised in chemical pathology in 2001 and has since worked at After spending 16 years practising in variousĭisciplines of clinical medicine including family practice, she The Faculty of Health Sciences at the University of the Witwatersrand Naicker is Senior Lecturer for the Department of Chemical Pathology in Jocelyn Naicker, BSc, MB ChB, MFGP (SA), FCPath (SA), MMed (Chem)Ĭhemical Pathologist, National Health Laboratory Service (NHLS),Ĭharlotte Maxeke Johannesburg Academic Hospital (CMJAH) Laboratory Glomerular filtration rate (GFR) and estimation of the GFR (eGFR) in adults The GFR is the best overall measure of renal function.
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